Research

Without research, there would be no progress. Research is therefore crucial to providing better care for patients both now and into the future. Associate Professor Grummet believes that it is the practising urological surgeon who is in the best position to lead clinical urological research.

The experience of daily clinical practice shows us where patient care is lacking and leads us to question how we might improve it. With the exponential rise of technological advances and the power of collaboration, we now have the opportunity to make great strides forward in a short period of time.

Inspired by the clinical research he experienced at The Prostate Centre at Vancouver General Hospital, Assoc Prof Grummet has since presented widely and published on his research projects. His areas of interest have been on the benefits of surgical treatment of high risk prostate cancer and on active surveillance for low risk prostate cancer.

Recognising that most of the controversies surrounding prostate cancer start with its diagnosis, Assoc Prof Grummet has now turned his research focus onto prostate cancer diagnostics including MRI and biopsy, and supervises Bachelor of Medical Science and Master of Surgery researchers in this field. Topics under investigation include the risk of biopsy sepsis, diagnostic accuracy, and the role of MRI-targeted biopsy.

At Australian Urology Associates, Assoc Prof Grummet and his research students have created one of the world's largest high quality databases on prostate MRI using the REDCap system.


Publications – Peer Reviewed
 

 

 

The who, when and how of PSA testing: new Australian Guidelines

Grummet J.
Medicine Today 2016; 17(6): 55-57.

 

Risk factors for infection following prostate biopsy

Anderson E, Leahy O, Cheng AC, Grummet J.
BMC Infect Dis. 2015 Dec 23;15(1): 580.

 

Current practice of prostate biopsy in Australia and New Zealand: A survey.

Davis P, Paul E, Grummet J.
Urol Ann. 2015: Jul-Sep; 7(3): 315-9.

 

The state of TRUS biopsy sepsis in Australia: Re-admissions to Victorian Hospitals with TRUS biopsy-related infection over 5 years.

Roth H, Millar J, Cheng A, Byrne A, Evans S, Grummet J.
BJU Int. 2015: Oct;116 Suppl 3:49-53. doi: 10.1111/bju13209.

 

Could MRI solve the prostate cancer conundrum?

Grummet J, O'Sullivan R.
Med J Aust 2015 May 4; 202(8): 410-11.
 


A high PSA level in a man with suspected prostatitis. It's just due to inflammation, right?

Grummet J.
Medicine Today 2015; 16(5); 61-62.
 


Testicular loss following bacterial epididymo-orchitis: Case report and literature review.

Fehily SR, Trubiano JA, McLean C, Teoh BW, Grummet JP, Cheery CL, Vujovoc O.
Can Urol Assoc J. 2015 Mar-Apr;9(3-4):E149-51.

 

Significant impact of transperineal template biopsy of the prostate at a single tertiary institution.

Huang S, Reeves F, Preece J, Satasivam P, Royce P, Grummet J.
Urology Annals 2015: Oct-Dec;7(4):428-32.



Patients with medical risk factors for chronic kidney disease are at increased risk of renal impairment despite the use of nephron-sparing surgery.

Satasivam P, Reeves S, Rao K, Ivey Z, Basto M, Yip M, Roth H, Grummet J, Goad J, Moon D, Appu S, Lawrentschuk N, Bolton D, Kearsley J, Costello A, Frydenberg M.
BJU Int. 2015 Oct;116(4):590-5. doi: 10.1111/bju.13075.


Penthrox alone versus Penthrox plus PILA for analgesia in TRUS-guided prostate biopsy.

Huang S, Pepdjonovic L, Konstantatos A, Frydenberg M, Grummet J.
ANZ J Surg 2015 Feb 5. doi: 10.1111/ans.12974.

 

Transperineal biopsy prostate cancer detection in first biopsy and post-negative TRUS biopsy settings: The Victorian Transperineal Biopsy Collaboration experience.

Ong WL, Weerakoon M, Huang S, Paul E, Lawrentschuk N, Frydenberg M, Moon D, Murphy D, Grummet J.
BJU Int. 2015 Oct;116(4):568-76. doi: 10.1111/bju.13031.



Primary apocrine adenocarcinoma of scrotum suspected as urothelial carcinoma metastasis: a clinical and pathological dilemma.

Sean Huang, Mark Frydenberg, Alan Pham, Jeremy P. Grummet.
Urology Annals. 2015 Jan;7(1):97-9.

 

TRUS biopsy sepsis and the rise of carbapenem antibiotic use.

Leahy O, O'Reilly M, Phillips D, Dyer D, Grummet J.
ANZ J Surg 2014 Dec;85(12):931-5. doi: 10.1111/ans.12933.

 

Sepsis and 'superbugs': should we favour the transperineal over the transrectal approach for prostate biopsy?

Grummet JP, Weerakoon M, Huang S, Lawrentschuk N, Frydenberg M, Moon DA, O'Reilly M, Murphy D.
BJU Int. 2014 Sep;114(3):384-8.

 

Is zero sepsis alone enough to justify transperineal prostate biopsy?

Murphy DG, Weerakoon M, Grummet J. 
BJU Int. 2014 Jul;114(1):3-4.

 

Trans-perineal prostate biopsy: template-guided or free-hand? 

Dundee PE, Grummet J, Murphy DG
BJU Int. 2014 May;115(5):681-3. doi: 10.1111/bju.12860.

 

A bioengineered microenvironment to quantitatively measure the tumorigenic properties of cancer-associated fibroblasts in human prostate cancer.

Clark AK, Taubenberger AV, Taylor RA, Niranjan B, Chea ZY, Zotenko E, Sieh S, Pedersen JS, Norden S, Frydenberg M, Grummet JP, Pook DW; Australian Prostate Cancer BioResource, Stirzaker C, Clark SJ, Lawrence MG, Ellem SJ, Hutmacher DW, Risbridger GP.
Biomaterials. 2013 Jul;34(20):4777-85.

 

Splash! The spontaneous rupture of a bladder diverticulum: a rare cause of an acute abdomen.

Leahy O, Grummet J.
ANZ J Surg. 2013 Oct;83(10):792-3.

 

The 'green whistle': a novel method of analgesia for transrectal prostate biopsy.

Grummet J, Huang S, Konstantatos A, Frydenberg M.
BJU Int. 2012 Dec;110 Suppl 4:85-8.

 

Radical prostatectomy for high-risk clinically localized prostate cancer: a prospective single institution series.

Koupparis AJ, Grummet JP, Hurtado-Coll A, Bell RH, Buchan N, Goldenberg SL, Gleave ME.
Can Urol Assoc J. 2011 Dec;5(6):E156-61.

 

Paraneoplastic syndromes in prostate cancer.

Hong MK, Kong J, Namdarian B, Longano A, Grummet J, Hovens CM, Costello AJ, Corcoran NM.
Nat Rev Urol. 2010 Dec;7(12):681-92.

 

Vesicourethral anastomosis with 2-octyl cyanoacrylate adhesive in an in vivo canine model.

Grummet JP, Costello AJ, Swanson DA, Stephens LC, Cromeens DM.
Urology. 2002 Nov;60(5):935-8.

 

Laser welded vesicourethral anastomosis in an in vivo canine model: a pilot study.

Grummet JP, Costello AJ, Swanson DA, Stephens LC, Cromeens DM.
J Urol. 2002 Jul;168(1):281-4.


Publications – Abstracts

2014

 

Transperineal biopsy streamlined.

Grummet J., Mann S., Grummet H., Murphy D.

BJU International. Conference: 67th Annual Scientific Meeting of the Urological Society of Australia and New Zealand Brisbane, QLD Australia. Conference Start: 20140316 Conference End: 20140319. Conference Publication: (var.pagings). 113 (pp 140), 2014. Date of Publication: March 2014.

 

Zero sepsis in 331 consecutive transperineal biopsies.

Grummet J., Weerakoon M., Huang S., Lawrentschuk N., Frydenberg M., Moon D., Murphy D.

BJU International. Conference: 67th Annual Scientific Meeting of the Urological Society of Australia and New Zealand Brisbane, QLD Australia. Conference Start: 20140316 Conference End: 20140319. Conference Publication: (var.pagings). 113 (pp 64), 2014. Date of Publication: March 2014.

 

Pathological outcomes of transperineal biopsy of the prostate - The Victorian Transperineal Biopsy Collaboration (VTBC) experience.

Ong W.L., Weerakoon M., Huang S., Lawrentschuk N., Frydenberg M., Moon D., Murphy D., Grummet J.

BJU International. Conference: 67th Annual Scientific Meeting of the Urological Society of Australia and New Zealand Brisbane, QLD Australia. Conference Start: 20140316 Conference End: 20140319. Conference Publication: (var.pagings). 113 (pp 39), 2014. Date of Publication: March 2014.

 

Analysis of outcomes and impact on clinical management with Transperineal Template Biopsy.

Huang S., Reeves F., Preece J., Satasivam P., Grummet J.

BJU International. Conference: 67th Annual Scientific Meeting of the Urological Society of Australia and New Zealand Brisbane, QLD Australia. Conference Start: 20140316 Conference End: 20140319. Conference Publication: (var.pagings). 113 (pp 118-119), 2014. Date of Publication: March 2014.

 

The state of TRUS biopsy sepsis. Re-admissions to all Victorian hospitals with TRUS biopsy infection over 5 years.

Roth H., Millar J., Cheng A., Byrne A., Evans S., Grummet J.

BJU International. Conference: 67th Annual Scientific Meeting of the Urological Society of Australia and New Zealand Brisbane, QLD Australia. Conference Start: 20140316 Conference End: 20140319. Conference Publication: (var.pagings). 113 (pp 42), 2014. Date of Publication: March 2014.

 

Comparison of two novel methods of TRUS biopsy analgesia: Methoxyflurane alone versus methoxyflurane plus local anaesthetic infiltration.

Ong W.L., Huang S., Pepdjonovic L., Konstantantos A., Frydenberg M., Grummet J.

BJU International. Conference: 67th Annual Scientific Meeting of the Urological Society of Australia and New Zealand Brisbane, QLD Australia. Conference Start: 20140316 Conference End: 20140319. Conference Publication: (var.pagings). 113 (pp 18-19), 2014. Date of Publication: March 2014.

 

Pathology of renal cell carcinoma in the state of Victoria.

Satasivam P., Rao K., Reeves F., Basto M., Ivey Z., Yip M., Roth H., Grummet J., Goad J., Appu S., Kearsley J., Moon D., Murphy D., Lawrentschuk N., Costello A., Bolton D., Frydenberg M.

BJU International. Conference: 67th Annual Scientific Meeting of the Urological Society of Australia and New Zealand Brisbane, QLD Australia. Conference Start: 20140316 Conference End: 20140319. Conference Publication: (var.pagings). 113 (pp 132-133), 2014. Date of Publication: March 2014.

 

Choosing the best surgical approach for T1b renal cell carcinoma.

Satasivam P., Reeves F., Rao K., Ivey Z., Basto M., Yip M., Roth H., Grummet J., Goad J., Moon D., Murphy D., Appu S., Lawrentschuk N., Bolton D., Kearsley J., Costello A., Frydenberg M.

BJU International. Conference: 67th Annual Scientific Meeting of the Urological Society of Australia and New Zealand Brisbane, QLD Australia. Conference Start: 20140316 Conference End: 20140319. Conference Publication: (var.pagings). 113 (pp 132), 2014. Date of Publication: March 2014.

 

The effect of clinical stage and lesion complexity on the practice of surgery for renal cell carcinoma in the state of Victoria.

Satasivam P., Rao K., Reeves F., Ivey Z., Basto M., Yip M., Roth H., Grummet J., Goad J., Moon D., Murphy D., Appu S., Kearsley J., Lawrentschuk N., Costello A., Bolton D., Frydenberg M.

BJU International. Conference: 67th Annual Scientific Meeting of the Urological Society of Australia and New Zealand Brisbane, QLD Australia. Conference Start: 20140316 Conference End: 20140319. Conference Publication: (var.pagings). 113 (pp 132), 2014. Date of Publication: March 2014. 

 

The presence of risk factors for chronic kidney disease may diminish the benefit of partial nephrectomy for renal cell carcinoma.

Satasivam P., Rao K., Reeves F., Basto M., Ivey Z., Yip M., Roth H., Grummet J., Goad J., Appu S., Kearsley J., Moon D., Murphy D., Lawrentschuk N., Costello A., Bolton D., Frydenberg M.

BJU International. Conference: 67th Annual Scientific Meeting of the Urological Society of Australia and New Zealand Brisbane, QLD Australia. Conference Start: 20140316 Conference End: 20140319. Conference Publication: (var.pagings). 113 (pp 42-43), 2014. Date of Publication: March 2014.

 

The adoption of routine pelvic lymphadenectomy may be associated with improved overall survival in patients undergoing radical cystectomy for bladder cancer.

Satasivam P., Roth H., Kerr S., Sivarajah G., Grummet J., Goad J., Brennan J.

BJU International. Conference: 67th Annual Scientific Meeting of the Urological Society of Australia and New Zealand Brisbane, QLD Australia. Conference Start: 20140316 Conference End: 20140319. Conference Publication: (var.pagings). 113 (pp 131), 2014. Date of Publication: March 2014.

 

Phase II study of neoadjuvant 'supercastration' in men with high-risk prostate cancer.

Corcoran N., Howard N., Bugeja P., Kerger M., Moon D., Clarke D., Grummet J., Hovens C., Costello T., Pedersen J., Ryan A., Ruljancich P., Parente P.

BJU International. Conference: 67th Annual Scientific Meeting of the Urological Society of Australia and New Zealand Brisbane, QLD Australia. Conference Start: 20140316 Conference End: 20140319. Conference Publication: (var.pagings). 113 (pp 18), 2014. Date of Publication: March 2014.

 

Epidemiology and contemporary management of traumatic bladder ruptures at an Australian major trauma centre.

Yao H.H.I., Grummet J., Esser M., Atkin C., Hanegbi U.

BJU International. Conference: 67th Annual Scientific Meeting of the Urological Society of Australia and New Zealand Brisbane, QLD Australia. Conference Start: 20140316 Conference End: 20140319. Conference Publication: (var.pagings). 113 (pp 29), 2014. Date of Publication: March 2014.


2013

TRUS biopsy sepsis and use of carbapenem antibiotics at a single high volume local institution.

Leahy O., O'Reilly M., Phillips D., Grummet J.

BJU International. Conference: Prostate Cancer World Congress and 14th Australasian Prostate Cancer Conference Melbourne, VIC Australia. Conference Start: 20130806 Conference End: 20130810. Conference Publication: (var.pagings). 112 (pp 26-27), 2013. Date of Publication: August 2013.

 

Sepsis and superbugs: Should transperineal biopsy be offered to all prospective prostate biopsy patients?

Grummet J., Weerakoon M., Huang S., Lawrentschuk N., Frydenberg M., Moon D., O'Reilly M., Murphy D.

BJU International. Conference: Prostate Cancer World Congress and 14th Australasian Prostate Cancer Conference Melbourne, VIC Australia. Conference Start: 20130806 Conference End: 20130810. Conference Publication: (var.pagings). 112 (pp 26), 2013. Date of Publication: August 2013.

 

Transperineal template biopsy of the prostate: A review of the impact at Alfred Health.

Huang S., Reeves F., Preece J., Grummet J.

BJU International. Conference: Prostate Cancer World Congress and 14th Australasian Prostate Cancer Conference Melbourne, VIC Australia. Conference Start: 20130806 Conference End: 20130810. Conference Publication: (var.pagings). 112 (pp 25-26), 2013. Date of Publication: August 2013.

 

Transperineal prostate biopsy: A comparison of two techniques.

Grummet J., Reeves F., Frydenberg M.

BJU International. Conference: 66th Annual Scientific Meeting of the Urological Society of Australia and New Zealand Melbourne, VIC Australia. Conference Start: 20130413 Conference End: 20130416. Conference Publication: (var.pagings). 111 (pp 99), 2013. Date of Publication: April 2013.

 

Current practices of prostate biopsy in Australia and New Zealand - the survey.

Grummet J., Davis P.

BJU International. Conference: 66th Annual Scientific Meeting of the Urological Society of Australia and New Zealand Melbourne, VIC Australia. Conference Start: 20130413 Conference End: 20130416. Conference Publication: (var.pagings). 111 (pp 96), 2013. Date of Publication: April 2013.

 

Evaluating Netwit and its usefulness in serving the purpose to connect all urologists within Australia.

Ow D., Woo H., Grummet J., Pokorny M.R., Lawrentschuk N.

BJU International. Conference: 66th Annual Scientific Meeting of the Urological Society of Australia and New Zealand Melbourne, VIC Australia. Conference Start: 20130413 Conference End: 20130416. Conference Publication: (var.pagings). 111 (pp 86-87), 2013. Date of Publication: April 2013.

 

Primary apocrine adenocarcinoma of scrotum suspected as urothelial carcinoma metastasis: A clinical and pathological dilemma.

Huang S., Frydenberg M., Pham A., Pedersen J., Grummet J.

BJU International. Conference: 66th Annual Scientific Meeting of the Urological Society of Australia and New Zealand Melbourne, VIC Australia. Conference Start: 20130413 Conference End: 20130416. Conference Publication: (var.pagings). 111 (pp 118), 2013. Date of Publication: April 2013.

 

Radical cystectomy: The benefit of lymph node density.

Pirpiris A., Rzetelski-West K., Grummet J.

BJU International. Conference: 66th Annual Scientific Meeting of the Urological Society of Australia and New Zealand Melbourne, VIC Australia. Conference Start: 20130413 Conference End: 20130416. Conference Publication: (var.pagings). 111 (pp 70), 2013. Date of Publication: April 2013.


2012

The green whistle: A novel method of analgesia for transrectal prostate biopsy.

Grummet J., Huang S., Konstantatos A., Frydenberg M.

Asia-Pacific Journal of Clinical Oncology. Conference: Annual Scientific Meeting of the Australian and New Zealand Urogenital and Prostate: State of the Art Multi-Disciplinary Care in Urological Cancers, ANZUP 2012 Sydney, NSW Australia. Conference Start: 20120715 Conference End: 20120717. Conference Publication: (var.pagings). 8 (pp 30-31), 2012. Date of Publication: July 2012.

 

The PRIAS study in Australia: One institution's experience.

Grummet J.P., Lin M.J.

BJU International. Conference: 65th Annual Scientific Meeting of the Urological Society of Australia and New Zealand Darwin, NT Australia. Conference Start: 20120421 Conference End: 20120424. Conference Publication: (var.pagings). 109 (pp 10-11), 2012. Date of Publication: April 2012.

 

Indications and pathological outcomes of radical cystectomy: A contemporary Australian series.

Kerr S., Satasivam P., Grummet J.

BJU International. Conference: 65th Annual Scientific Meeting of the Urological Society of Australia and New Zealand Darwin, NT Australia. Conference Start: 20120421 Conference End: 20120424. Conference Publication: (var.pagings). 109 (pp 38-39), 2012. Date of Publication: April 2012.


2010

Metastatic prostate cancer presenting as a syndrome of inappropriate antidiuretic hormone secretion.

Kong J.P.L., Bultitude M.F., Longano A., Grummet J., Corcoran N.M.

BJU International. Conference: Urological Society of Australia and New Zealand 63rd Annual Scientific Meeting Perth, WA United States. Conference Start: 20100221 Conference End: 20100224. Conference Publication: (var.pagings). 105 (pp 28), 2010. Date of Publication: February 2010.

 

Painful scrotal swelling in adolescent boys and men.

Grummet J., Frydenberg M.

Medicine Today. 11 (4) (pp 81-82), 2010. Date of Publication: April 2010.


Other Presentations 

August 2012: 13th Australasian Prostate Cancer Conference, Melbourne – “Transperineal Template Biopsy of the Prostate: the Initial Alfred Experience”

October 2010: 5th Annual International Academic Week, Sir Run Run Shaw Hospital, Hangzhou, China – “Active Surveillance for Low Risk Prostate Cancer”

August 2010: 11th National Prostate Cancer Symposium, Melbourne – Co-Chair session with Dr Peter Scardino on Active Surveillance of Low Risk Prostate Cancer

March 2009: USANZ ASM, Gold Coast – “Surgery For High Risk Clinically Localised Prostate Cancer: Surgical Pathology and PSA Recurrence-Free Survival”

June 2008: CUA Annual Meeting, Edmonton, Canada - “Radical Prostatectomy for High Risk Prostate Cancer: the Vancouver Experience”; received Five Star Distinction for abstract

February 2008: Genitourinary Cancers Symposium, San Francisco, California – “Radical Prostatectomy for High Risk Prostate Cancer: the Vancouver Experience”; received Merit Award for abstract

December 2007: North West Urological Society Annual Meeting, Vancouver, Canada – “Radical Prostatectomy for High Risk Prostate Cancer: the Vancouver Experience”; also presented on “Surgery for High Risk Prostate Cancer” at sponsored symposium session; moderated Bladder Cancer session

October 2007: Western Section AUA Annual Meeting, Scottsdale, Arizona – “Radical Prostatectomy for High Risk Prostate Cancer: the Vancouver Experience”

October 2006: USANZ Annual Victorian State Meeting, SheppartonWinner 3rd Prize Best Presentation for “Laparoscopic Partial Nephrectomy – the Royal Melbourne Hospital Experience”

March 2006: Urological Society of Australasia ASM, Brisbane – “Perks, Freebies and Incentives: Zero Ethical Responsibility?”

March 2003: Urological Society of Australasia ASM, Queenstown, New Zealand - “Could BioGlue Replace Sutures for Anastomosis in Laparoscopic Radical Prostatectomy?”

August 2002: 3rd National Prostate Cancer Symposium, Melbourne -“Non-sutured Vesico-urethral Anastomosis in Radical Prostatectomy”

April 2002: Urological Society of Australasia ASM, Perth. - “Anastomosis in Radical Prostatectomy: A Better Way Using Glue?”                        

January 2002: SPIE Conference on Laser Welding and Soldering of Tissue, San Jose, California - “Laser Welded Urinary Tract Anastomosis in an In Vivo Canine Model”.

October 2001: Urological Society of Australasia Annual Victorian State Meeting, Rosebud - “Novel Techniques for a Watertight Anastomosis in Radical Prostatectomy”.


Current Trials

2015- : Principal investigator and original concept author of Painfree TRUS B, a randomised control trial comparing novel methods of pain relief for patients during prostate biopsy. Awarded competitive grant funding of nearly $600,000 from Cancer Australia and PCFA.

2014- : Co-investigator for the ASTROID trial, assessing a decision aid for active surveillance in patients diagnosed with low risk prostate cancer.

2014- : Site investigator for the ENZAMET trial, a randomised control trial assessing the therapeutic effect of Enzalutamide on newly-diagnosed metastatic prostate cancer.

2013-4: Co-investigator for the Duodart and sexual dysfunction trial, an international randomized placebo-controlled study of the effects of Duodart on sexual function.

2012-4: Co-investigator for the Diphereline and LUTS study, a national observational study of the effect of LHRH agonist on LUTS in men with advanced prostate cancer.

2010- : Site investigator at Alfred Hospital site for PRIAS, an international observational study in active surveillance for prostate cancer.


Master of Surgery

2001-4: Enrolled in a Master of Surgery. Conducted full-time research in the Department of Veterinary Medicine and Surgery of University of Texas M.D. Anderson Cancer Center in Houston, Texas in 2001. The techniques of laser tissue welding and use of biological adhesives were investigated for performing the anastomosis (join) between the bladder and urethra in radical prostatectomy. The longer-term follow-up project was conducted at University of Melbourne Department of Veterinary Science.

The thesis, entitled Novel Techniques for Vesico-Urethral Anastomosis in Radical Prostatectomy, was accepted and the degree of Master of Surgery conferred in 2004.